| 
| Zondag | 05/09/2021 | 10:00 | 
| Blue Tigers - Dynamo Bertem | 33-78 |
|
| Zondag | 19/09/2021 | 12:00 |
| Blue Tigers - Jets Basket Zaventem | 20-0 (FF) |
O |
| Zaterdag | 25/09/2021 | 17:00 |
| Royal BC Alleur - Notre Dame |
|
|
| Zaterdag | 02/10/2021 | 14:00 |
| Red Dragons Huldenberg - Blue Tigers |
|
|
| Zaterdag | 09/10/2021 | 10:00 |
| GSG Aarschot - Blue Tigers | 0-76 |
|
| Zondag | 17/10/2021 | 12:00 |
| Blue Tigers - Stella Artois Leuven Bears | 49-21 |
|
| Zondag | 24/10/2021 | 12:00 |
| Jets Basket Zaventem - Blue Tigers | 16-40 |
B |
| Zaterdag | 30/10/2021 | 11:00 |
| Blue Tigers - BC Asse-Ternat | 9-120 |
|
| Zondag | 14/11/2021 | 11:00 |
| Dynamo Bertem - Blue Tigers | 41-30 |
|
| Zondag | 21/11/2021 | 10:00 |
| Blue Tigers - GSG Aarschot | 80-11 |
|
| Zaterdag | 27/11/2021 | 09:00 |
| Stella Artois Leuven Bears - Blue Tigers | 9-50 |
|
| Zondag | 05/12/2021 | 14:00 |
| Blue Tigers - Red Dragons Huldenberg |
|
B |
| Zondag | 12/12/2021 | 11:00 |
| BC Opwijk - Blue Tigers |
|
B |
| Zondag | 09/01/2022 | 12:00 |
| Blue Tigers - Hageland United |
|
