O | 
| Zaterdag | 14/08/2021 | 14:00 | 
| Femina Habac Sint-Truiden - Blue Tigers | 33-34 |
O |
| Zondag | 29/08/2021 | 10:00 |
| Blue Tigers - Kangoeroes Basket Mechelen | 48-52 |
O |
| Zondag | 05/09/2021 | 12:00 |
| Blue Tigers - Londerzeelse Dunkers | 74-18 |
|
| Zondag | 12/09/2021 | 11:00 |
| DBC Osiris Okapi Aalst - Blue Tigers | 13-76 |
|
| Zondag | 19/09/2021 | 10:00 |
| Blue Tigers - BC Asse-Ternat | 87-20 |
|
| Zondag | 03/10/2021 | 12:00 |
| Blue Tigers - DBC Osiris Okapi Aalst | 67-20 |
|
| Zaterdag | 09/10/2021 | 09:00 |
| Kangoeroes Basket Mechelen - Blue Tigers | 45-42 |
|
| Zondag | 31/10/2021 | 14:30 |
| BC Asse-Ternat - Blue Tigers | 33-59 |
|
| Zondag | 07/11/2021 | 10:00 |
| Blue Tigers - Molenbeek Rebels Basketball | 121-11 |
|
| Zaterdag | 13/11/2021 | 14:45 |
| Molenbeek Rebels Basketball - Blue Tigers | 31-115 |
|
| Zondag | 21/11/2021 | 10:00 |
| Blue Tigers - Kangoeroes Basket Mechelen | 52-50 |
O |
| Zaterdag | 04/12/2021 | 17:30 |
| Hageland United - Notre Dame |
|
